Multiple endocrine neoplasia A group of conditions affecting the endocrine glands. MEN IIb is of particular relevance as it consists of multiple mucosal neuromas which have a characteristic histopathology, pheochromocytoma, medullary thyroid carcinoma, and a thin wasted appearance. Calcitonin levels are elevated if medullary thyroid carcinoma is present. Index of suspicion should be high in tall, thin, wasted-looking children and young adults presenting with lumps in the mouth. Biopsy is mandatory and if histopathology is suggestive the thyroid must be adequately investigated. This is another 'worthwhile' syndrome.